October 10, 2024

Sigma2 Receptors

The Auto-Abs against the three proteins have high specificity, as indicated by the statistically significant stronger binding towards the peptides containing the three 6-mers (see Figure 1, -panel B and Outcomes) and by the IgG binding to 15-aa longer peptides containing the 6-mer epitopes flanked by irrelevant GS repeats (Figure S1)
4 min read

The Auto-Abs against the three proteins have high specificity, as indicated by the statistically significant stronger binding towards the peptides containing the three 6-mers (see Figure 1, -panel B and Outcomes) and by the IgG binding to 15-aa longer peptides containing the 6-mer epitopes flanked by irrelevant GS repeats (Figure S1)

cmerp February 19, 2023
The Auto-Abs against the three proteins have high specificity, as indicated by the statistically significant stronger binding...
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Even though the confirmed PR rate was only 12% in the first 25 evaluable patients (all platinum-resistant patients), the 6-month PFS rate of 56% (14 of 25) met the efficacy criteria, justifying progression to second-stage accrual
6 min read

Even though the confirmed PR rate was only 12% in the first 25 evaluable patients (all platinum-resistant patients), the 6-month PFS rate of 56% (14 of 25) met the efficacy criteria, justifying progression to second-stage accrual

cmerp December 12, 2022
Even though the confirmed PR rate was only 12% in the first 25 evaluable patients (all platinum-resistant...
Read More

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(B) Proliferation with increasing focus of ruxolitinib in accordance with proliferation in the current presence of DMSO control is depicted for Ba/F3 cells transduced with EPOR coexpressing either Jak2 WT, Jak2S523L, Jak2V617F, or Jak2K539L
4 min read

(B) Proliferation with increasing focus of ruxolitinib in accordance with proliferation in the current presence of DMSO control is depicted for Ba/F3 cells transduced with EPOR coexpressing either Jak2 WT, Jak2S523L, Jak2V617F, or Jak2K539L

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RhoGDI, which is a universally expressed RhoGDI, was stained using anti-RhoGDI antibody (sc-360) like a loading control
3 min read

RhoGDI, which is a universally expressed RhoGDI, was stained using anti-RhoGDI antibody (sc-360) like a loading control

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Dynabeads proteins G was added and incubated for 2 then?h
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Dynabeads proteins G was added and incubated for 2 then?h

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In experiments where RNAi was less efficient, hardly any reduction in nuclear export could be observed
3 min read

In experiments where RNAi was less efficient, hardly any reduction in nuclear export could be observed

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