Another clinical sign that is also usually seen, referred to in literature as numb chin syndrome (NCS), occurs because of the involvement of the inferior alveolar branch of the mandibular nerve [7]. (CA) 5 years previous, and since then, he had visited his doctor periodically for an annual examination. In these examinations and on the basis of tests carried out at the hospital 1 year previous, it was stated that no CA relapse traces were detected. The patient had visited his dentist 2 months previous for pain and numbness of the left molar region. == Conclusions == We report numb chin syndrome, which is an uncommon neurological manifestation of metastatic malignancy. The clinical course and rapid deterioration after the initial presentation of this syndrome is discussed. This clinical situation illustrates the importance of good medical history review prior to all procedures by the medical professions dealing with oncology patients. An awareness of this condition is crucial, especially in symptoms with unexplained facial pain and numbness. Keywords: distant metastasis, jaws, cone beam computed tomography, numb chin syndrome == Background == Secondary Cdx1 malignancy of the jaws is uncommon, and when encountered, such cases may be diagnostically challenging. About 1% of oral cancers, which are located in the soft tissues and jaws, are metastases of primary tumors located elsewhere in the body [1]. The identification of these lesions, particularly soft tissue metastasis, Ambroxol can become a real diagnostic challenge because their clinical aspects can easily be mistaken for pyogenic granuloma, peripheral giant cell granuloma, or epulis [2]. The mandible is the most common site of metastasis of the oral region. The most common location is the molar region of the mandible, and the common primary lesions are located in the breast, adrenal gland, genital organs, thyroid gland, lung, prostate, and kidney [3]. Prostate CA prefers the jawbone because of its significant red marrow component as a metastatic target; for example , 11% of the jawbone metastases in men originated from the prostate gland compared with 1 . 5% in those metastases found in soft tissues [4]. The differentiation between primary tumor and metastasis is an important aspect. The histopathology of these lesions is very important. The appearance of oral metastatic lesions is a sign of advanced-stage malignant disease, with multiple metastases in other locations [5]. In some cases metastasis may develop in a recent post-extraction socket or even in the alveolar zone before extraction, giving rise to the indication of tooth removal [6]. The clinical presentation simulates common pathological conditions such as toothache, Ambroxol osteomyelitis, inflammatory hyperplasia, temporomandibular joint pain, trigeminal neuralgia, periodontal conditions, pyogenic or giant cell granuloma [6, 7], and accordingly, it may be difficult to diagnose such cases. Another clinical sign that is also usually seen, referred to in literature as numb chin syndrome (NCS), occurs because of the involvement of the inferior alveolar branch of the mandibular nerve [7]. NCS is a sensory neuropathy that includes perineural Ambroxol spread of metastatic disease. Special attention should be given to patients with this syndrome, which should always raise the suspicion of a metastatic disease in the mandible [8]. The purpose of this Ambroxol report was to describe the clinical and radiological findings of numb chin syndrome as a manifestation a prostate carcinoma metastasis. == Case presentation == A 78-year-old male patient presented to our outpatient clinic with a complaint of numbness and pain on the left site of the mandible. The patient stated that he had been suffering from this numbness for 1to 2 months. In the medical anamnesis, it was discovered that patient suffered from prostate CA 5 years previous, and since then he had visited his doctor periodically for an annual examination. In the examinations and on the basis of tests carried out at the hospital 1 year previous, it was stated that no CA.