January 24, 2025

Nociceptin Receptors

A main exemplory case of this is actually the known fact that studies in cynomolgus macaques, one of the most prevalent from the NHP versions used, didn’t identify the chance of uncontrolled T cell activation and cytokine storm that accompanied clinical usage of the cross-linking anti-CD28 agonist targeting the CD loop of CD28, TGN1412(68), likely because of the insufficient expression of CD28 on CD4+ effector cells in macaques, and its own increased expression over the individual counterpart
4 min read

A main exemplory case of this is actually the known fact that studies in cynomolgus macaques, one of the most prevalent from the NHP versions used, didn’t identify the chance of uncontrolled T cell activation and cytokine storm that accompanied clinical usage of the cross-linking anti-CD28 agonist targeting the CD loop of CD28, TGN1412(68), likely because of the insufficient expression of CD28 on CD4+ effector cells in macaques, and its own increased expression over the individual counterpart

cmerp July 31, 2022
A main exemplory case of this is actually the known fact that studies in cynomolgus macaques, one...
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