October 10, 2024

cmerp

Here, finding that inhibitory neurotransmitter glycine does not activate KCNQs, we re-engineered it in silico to expose expected KCNQ-opening properties, screened by in silico docking, then validated the hits in vitro
3 min read

Here, finding that inhibitory neurotransmitter glycine does not activate KCNQs, we re-engineered it in silico to expose expected KCNQ-opening properties, screened by in silico docking, then validated the hits in vitro

cmerp October 25, 2021
Here, finding that inhibitory neurotransmitter glycine does not activate KCNQs, we re-engineered it in silico to expose...
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CF?=?cleaved fragment (n?=?3) and (E) Immunofluorescence staining of apoptosis (TUNEL) display that VEDT induced apoptosis in (Mia-GFP) cells compared to vehicle (Veh) after 24?h and apoptosis was rescued in (Mia-FLIP) cells compared to vehicle (Veh) (n?=?3)
1 min read

CF?=?cleaved fragment (n?=?3) and (E) Immunofluorescence staining of apoptosis (TUNEL) display that VEDT induced apoptosis in (Mia-GFP) cells compared to vehicle (Veh) after 24?h and apoptosis was rescued in (Mia-FLIP) cells compared to vehicle (Veh) (n?=?3)

cmerp October 22, 2021
CF?=?cleaved fragment (n?=?3) and (E) Immunofluorescence staining of apoptosis (TUNEL) display that VEDT induced apoptosis in (Mia-GFP)...
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Genes overlapping between current DEGs and all genes differentially expressed between ethanol and control groups from your 2016 study were also under-represented (14 out of 552; < 0
3 min read

Genes overlapping between current DEGs and all genes differentially expressed between ethanol and control groups from your 2016 study were also under-represented (14 out of 552; < 0

cmerp October 18, 2021
Genes overlapping between current DEGs and all genes differentially expressed between ethanol and control groups from your...
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Although Vps34 is crucial in PI(3)P generation, once we verified in Figure ?Shape5F,5F, for autophagosome formation [7], it’s been suggested to become dispensable for the procedure [57-59], but necessary for autophagosome maturation since Vps34 is crucial in endosomal/lysosomal trafficking [53, 55] (see Dialogue for additional information)
3 min read

Although Vps34 is crucial in PI(3)P generation, once we verified in Figure ?Shape5F,5F, for autophagosome formation [7], it’s been suggested to become dispensable for the procedure [57-59], but necessary for autophagosome maturation since Vps34 is crucial in endosomal/lysosomal trafficking [53, 55] (see Dialogue for additional information)

cmerp October 15, 2021
Although Vps34 is crucial in PI(3)P generation, once we verified in Figure ?Shape5F,5F, for autophagosome formation [7],...
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The plateau in the OD600 seen for BC30 may represent a problem with solubility at higher concentrations or too little stability whereby the PDE isn’t inhibited long plenty of allowing growth to saturation
4 min read

The plateau in the OD600 seen for BC30 may represent a problem with solubility at higher concentrations or too little stability whereby the PDE isn’t inhibited long plenty of allowing growth to saturation

cmerp October 10, 2021
The plateau in the OD600 seen for BC30 may represent a problem with solubility at higher concentrations...
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(B) Proliferation with increasing focus of ruxolitinib in accordance with proliferation in the current presence of DMSO control is depicted for Ba/F3 cells transduced with EPOR coexpressing either Jak2 WT, Jak2S523L, Jak2V617F, or Jak2K539L
4 min read

(B) Proliferation with increasing focus of ruxolitinib in accordance with proliferation in the current presence of DMSO control is depicted for Ba/F3 cells transduced with EPOR coexpressing either Jak2 WT, Jak2S523L, Jak2V617F, or Jak2K539L

October 10, 2024
RhoGDI, which is a universally expressed RhoGDI, was stained using anti-RhoGDI antibody (sc-360) like a loading control
3 min read

RhoGDI, which is a universally expressed RhoGDI, was stained using anti-RhoGDI antibody (sc-360) like a loading control

October 8, 2024
Dynabeads proteins G was added and incubated for 2 then?h
4 min read

Dynabeads proteins G was added and incubated for 2 then?h

October 7, 2024
In experiments where RNAi was less efficient, hardly any reduction in nuclear export could be observed
3 min read

In experiments where RNAi was less efficient, hardly any reduction in nuclear export could be observed

October 7, 2024