October 10, 2024

Month: July 2022

A main exemplory case of this is actually the known fact that studies in cynomolgus macaques, one of the most prevalent from the NHP versions used, didn’t identify the chance of uncontrolled T cell activation and cytokine storm that accompanied clinical usage of the cross-linking anti-CD28 agonist targeting the CD loop of CD28, TGN1412(68), likely because of the insufficient expression of CD28 on CD4+ effector cells in macaques, and its own increased expression over the individual counterpart
4 min read

A main exemplory case of this is actually the known fact that studies in cynomolgus macaques, one of the most prevalent from the NHP versions used, didn’t identify the chance of uncontrolled T cell activation and cytokine storm that accompanied clinical usage of the cross-linking anti-CD28 agonist targeting the CD loop of CD28, TGN1412(68), likely because of the insufficient expression of CD28 on CD4+ effector cells in macaques, and its own increased expression over the individual counterpart

cmerp July 31, 2022
A main exemplory case of this is actually the known fact that studies in cynomolgus macaques, one...
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At 3 weeks, host vessels infiltration toward the center of the construct was reported only for the HA-FIB group, giving rise to a process eventually leading to the breakdown of the tissue-engineered cartilage at later time points (Fig
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At 3 weeks, host vessels infiltration toward the center of the construct was reported only for the HA-FIB group, giving rise to a process eventually leading to the breakdown of the tissue-engineered cartilage at later time points (Fig

cmerp July 28, 2022
At 3 weeks, host vessels infiltration toward the center of the construct was reported only for the...
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[PubMed] [Google Scholar] (17) Onda M, Beers R, Xiang L, Lee B, Weldon JE, Kreitman RJ, and Pastan We (2011) Recombinant immunotoxin against B-cell malignancies without immunogenicity in mice by removal of B-cell epitopes
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[PubMed] [Google Scholar] (17) Onda M, Beers R, Xiang L, Lee B, Weldon JE, Kreitman RJ, and Pastan We (2011) Recombinant immunotoxin against B-cell malignancies without immunogenicity in mice by removal of B-cell epitopes

cmerp July 25, 2022
[PubMed] [Google Scholar] (17) Onda M, Beers R, Xiang L, Lee B, Weldon JE, Kreitman RJ, and...
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As shown in Figure 7B, the levels of phosphorylated Erk and Jnk proteins decreased when the cells were treated with TR0304 and TR0506, whereas the levels of Cleaved Caspase-3 increased after treatments, confirming the involvement of the same intracellular pathways downstream of PD-L1 and PD-1, affected by their parental mAbs [33]
3 min read

As shown in Figure 7B, the levels of phosphorylated Erk and Jnk proteins decreased when the cells were treated with TR0304 and TR0506, whereas the levels of Cleaved Caspase-3 increased after treatments, confirming the involvement of the same intracellular pathways downstream of PD-L1 and PD-1, affected by their parental mAbs [33]

cmerp July 19, 2022
As shown in Figure 7B, the levels of phosphorylated Erk and Jnk proteins decreased when the cells...
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(B) Proliferation with increasing focus of ruxolitinib in accordance with proliferation in the current presence of DMSO control is depicted for Ba/F3 cells transduced with EPOR coexpressing either Jak2 WT, Jak2S523L, Jak2V617F, or Jak2K539L
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(B) Proliferation with increasing focus of ruxolitinib in accordance with proliferation in the current presence of DMSO control is depicted for Ba/F3 cells transduced with EPOR coexpressing either Jak2 WT, Jak2S523L, Jak2V617F, or Jak2K539L

October 10, 2024
RhoGDI, which is a universally expressed RhoGDI, was stained using anti-RhoGDI antibody (sc-360) like a loading control
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RhoGDI, which is a universally expressed RhoGDI, was stained using anti-RhoGDI antibody (sc-360) like a loading control

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Dynabeads proteins G was added and incubated for 2 then?h
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Dynabeads proteins G was added and incubated for 2 then?h

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In experiments where RNAi was less efficient, hardly any reduction in nuclear export could be observed
3 min read

In experiments where RNAi was less efficient, hardly any reduction in nuclear export could be observed

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